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Pascal F. Durrenberger Francesca S. Fernando Samira N. Kashefi Tim P. Bonnert Danielle Seilhean Brahim Nait-Oumesmar Andrea Schmitt Peter J. Gebicke-Haerter Peter Falkai Edna Grünblatt Miklos Palkovits Thomas Arzberger Hans Kretzschmar David T. Dexter Richard Reynolds 《Journal of neural transmission (Vienna, Austria : 1996)》2015,122(7):1055-1068
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Clinical and molecular characterization of seven Egyptian families with autosomal recessive robinow syndrome: Identification of four novel ROR2 gene mutations 下载免费PDF全文
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The Relationship between AKI and CKD in Patients with Type 2 Diabetes: An Observational Cohort Study
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Rana Jahanban‐Esfahlan Khaled Seidi Maryam Majidinia Ansar Karimian Bahman Yousefi Seyed Mohammad Nabavi Akram Astani Ioana Berindan‐Neagoe Diana Gulei Francesca Fallarino Marco Gargaro Giorgia Manni Matteo Pirro Suowen Xu Mahmoud Sadeghi Seyed Fazel Nabavi Samira Shirooie 《Reviews in medical virology》2019,29(4)
Seropositivity for HSV reaches more than 70% within the world population, and yet no approved vaccine exists. While HSV1 is responsible for keratitis, encephalitis, and labialis, HSV2 carriers have a high susceptibility to other STD infections, such as HIV. Induction of antiviral innate immune responses upon infection depends on a family of pattern recognition receptors called Toll‐like receptors (TLR). TLRs bridge innate and adaptive immunity by sensing virus infection and activating antiviral immune responses. HSV adopts smart tricks to evade innate immunity and can also manipulate TLR signaling to evade the immune system or even confer destructive effects in favor of virus replication. Here, we review mechanisms by which HSV can trick TLR signaling to impair innate immunity. Then, we analyze the role of HSV‐mediated molecular cues, in particular, NF‐κB signaling, in promoting protective versus destructive effects of TLRs. Finally, TLR‐based therapeutic opportunities with the goal of preventing or treating HSV infection will be discussed. 相似文献
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Marcello Fonseca Salgado‐Filho Samira Saady Morhy Henrique Doria de Vasconcelos Eric Benedet Lineburger Fabio de Vasconcelos Papa Eduardo Souza Leal Botelho Marcelo Ramalho Fernandes Maurício Daher David Le Bihan Chiara Scaglioni Tessmer Gatto Cláudio Henrique Fischer Alexander Alves da Silva Carlos Galhardo Júnior Carolina Baeta Neves Alexandre Fernandes Marcelo Luiz Campos Vieira 《Brazilian Journal of Anesthesiology》2018,68(1):1-32
Through the Life Cycle of Intraoperative Transesophageal Echocardiography (ETTI/SBA) the Brazilian Society of Anesthesiology, together with the Department of Cardiovascular Image of the Brazilian Society of Cardiology (DIC/SBC), createded a task force to standardize the use of intraoperative transesophageal echocardiography by Brazilian anesthesiologists and echocardiographers based on scientific evidence from the Society of Cardiovascular Anesthesiologists/American Society of Echocardiography (SCA/ASE) and the Brazilian Society of Cardiology. 相似文献
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Riadh Nciri Ezzeddine Bourogaa Samira Jbahi Mohamed Salah Allagui Abdelfattah Elfeki Christian Vincent Franoise Croute 《中国神经再生研究》2014,9(7):735-740
To investigate the molecular mechanism underlying the neuroprotective effect of lithium on cells, in this study, we exposed SH-SY5Y cells to 0.5 mmol/L lithium carbonate(Li2CO2) for 25–50 weeks and then detected the expression levels of some neurobiology related genes and post-translational modifications of stress proteins in SH-SY5Y cells. cDNA arrays showed that pyruvate kinase 2(PKM2) and calmodulin 3(CaM 3) expression levels were significantly down-regulated, phosphatase protein PP2A expression was lightly down-regulated, and casein kinase II(CK2), threonine/tyrosine phosphatase 7(PYST2), and dopamine beta-hydroxylase(DBH) expression levels were significantly up-regulated. Besides, western blot analysis of stress proteins(HSP27, HSP70, GRP78 and GRP94) showed an over-expression of two proteins: a 105 kDa protein which is a hyper-phosphorylated isoform of GRP94, and a 108 kDa protein which is a phosphorylated tetramer of HSP27. These results suggest that the neuroprotective effects of lithium are likely related to gene expressions and post-translational modifications of proteins cited above. 相似文献